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Dr. A. Jesu Arockia Raj

Ph. D (2002) Manonmaniam Sundaranar University, Tirunelveli, India

Professor

Dr. A. Jesu Arockia Raj, Professor of Life Sciences division at SRM Research Institute and associated with the Department of Biotechnology of SRM Institute of Science and Technology, since June 2012. He received his doctoral degree from Manonmaniam Sundaranar University, Tirunelveli, India during February 2002. Then, he moved to different Universities between 2003 and 2012 for his postdoctoral research. He developed his experience on fish biochemistry especially on fatty acid metabolism and regulation in marine fishes at Shantou University, China. At Ben-Gurion University of the Negev, Israel he established such a system of desert aquaculture engineering to culture marine fishes in desert waters. Further, at Jeju National University, South Korea followed by University of Malaya, Malaysia he concentrated on construction of cDNA libraries for varies commercially important aquatic organisms including fish, shellfish and aquatic algae. Presently at SRMIST, he focused on development of transcriptome database for aquatic organisms to address the immunological parameters including cloning, sequencing, molecular characterization, gene expression, recombinant protein expression and purification.

Academic Profile

  • Ph. D (2002) Manonmaniam Sundaranar University, Tirunelveli, India
  • M.Phil (1998) Manonmaniam Sundaranar University, Tirunelveli, India
  • M. Sc (1997) Manonmaniam Sundaranar University, Tirunelveli, India
  • B.Sc (1995) Manonmaniam Sundaranar University, Tirunelveli, India

Employment details

  • Professor (June 2018 - till date), SRM Research Institute, SRM Institute of Science and Technology, Kattankulathur, India
  • DBT- Ramalingaswami Fellow (Assoc. Professor) (2012-2018) Dept. of Biotechnology, Faculty of Science and Humanities, SRMIST, Kattankulathur 
  • Postdoctoral Fellow (2010-2012) Institute of Biological Sciences, Faculty of Science, University of Malaya, Malaysia
  • Postdoctoral Research Associate (2009-2010) Dept. of Biotechnology, School of Bio-Medical Sciences, Jeju National University, South Korea
  • Postdoctoral Fellow (2007-2009) The Jacob Blaustein Institute for Scientific Cooperation, Ben-Gurion University of the Negev, Israel
  • Research Associate (2005-2007) Jovika Media Pvt. Ltd, Chennai, India
  • Postdoctoral Fellow (2003-2005) Department of Biology, Shantou University, China

Awards & Recognitions

  • Visiting Professorship (2017), Univerisiti Putra Malaysia, Malaysia
  • Tamil Nadu Young Scientist Award 2014 in Biological Sciences, Academy of Science, Chennai
  • Young Scientist, Science and Engineering Research Board, Department of Science & Technology, Government of India, New Delhi.
  • DBT's Prestigious Ramalingaswami Re-entry Fellowship, Department of Biotechnology, Government of India, New Delhi
  • Distinguished Bright Spark Fellowship, University of Malaya, Malaysia
  • BK 21 Postdoctoral Research Fellowship, Jeju National University, South Korea
  • Jacob Blaustein Postdoctoral Fellowship, Ben-Gurion University of the Negev, Israel
  • Budding Scientist, All India Radio, Tirunelveli
  • Indian Council of Agricultural Research (ICAR) Research Fellowship, Ministry of Agriculture, New Delhi
  • Tamil Nadu State Council of Science and Technology Project Fellowship, Directorate of Collegiate Education, Chennai

Membership

  • Society of Fisheries Technologists (SOFT), Cochin, India
  • Society of Aquaculture Professionals (SAP), Chennai, India
  • Indian Nano-Biologists Association (INBA), Chennai, India
  • Indian Science Congress Association, Kolkata, India
  • Construction of transcriptome dataset for freshwater prawn Machrobrachium rosenbergii, freshwater fish striped murrel Channa striatus, marine fish rock bream Oplegnathus fasciatus, marine flatfish olive flounder Paralichthys olivaceus, marine shellfish Manila clam Venerupis philippinarum, Spirulina Spirulina platensis and Fungus Aphanomyces invadans.
  • Identification, isolation, sequencing and bio-informatics characterization of the immune related genes from the transcriptome.
  • Studies on the relative gene expression in various tissues of the above said experimental animals using quantitative real time PCR. Studies on the mRNA expression and transcriptional analysis upon microbial infection.
  • Cloning the coding sequence of the immune genes and purify the recombinant protein to study the gene specific protein activity analysis.
  • Identification of short peptides (antimicrobial and antioxidant) using bioinformatics tools from trancriptome database and synthesis the peptides to study its various activities.
  • So far, 285 defense genes have been identified and sequenced from different commercially important finfish and shellfish for molecular characterization studies; and the sequences were submitted to NCBI and EMBL nucleotides databases under various GenBank Accession IDs.

Research Area

  • Bioinformatics
  • Molecular Biology
  • Molecular Immunology
  • Antimicrobial Peptides
  • Free radical Biology
  • Pathology

Major Research Facilities Available

  • Cell culture unit
  • Molecular Immunology
  • Gene expression studies (qRT-PCR)
  • 2D gel Electrophoresis
  • Microbiology unit

Research projects

S.No

Title of the project

Funding Agency  & Reference  No.

Role in the Project

Status

Amount (Rs. in lakh)

1.

cDNA profiling in targeting novel immune related genes in epizootic ulcerative syndrome (EUS) infected striped murrel Channa striatus

Department of Biotechnology, Government of India, New Delhi

 

 

PI

Completed

(June 2012-May 2018)

 

  101.9

2.

Molecular and proteomic identification of immune related genes in freshwater prawn Macrobrachium rosenbergii

Science & Engineering Research Board (SERB), Department of Science & Technology, Government of India, New Delhi

 

 

PI

Completed

(August 2012- July 2015)

 

  18.1

3.

Virulence factors identification in fish disease [epizootic ulcerative syndrome (EUS)] causing fungus Aphanomyces invadans by transcriptome approach

Department of Biotechnology, Government of India, New Delhi

 

PI

On-going (October 2016- September 2019)

 

36.952

4.

Characterization of cellular and molecular mechanisms involved in fish lectins and its potential role in innate immune defense and therapeutics

Science & Engineering Research Board (SERB), Department of Science & Technology, Government of India, New Delhi

 

Co-PI

On-going (November 2016- October 2019)

 

39.8552

5.

102nd EC meeting on Science and Technology for Women

 

Science for Equity Empowerment and Development Division, Department of Science & Technology, Government of India

Coordinator

Completed

(April 2016- March 2017)

10.29

Patents Filed

  • A. JESU AROCKIARAJ, M. Kasi Vishwanathan, N. Prashanth Bhatt, Venkatesh Kumaresan and Rajesh Palanisamy (2019) A STABLE GEL-BASED SPIRULINA AQUAFEED AND METHOD FOR ITS PREPARATION. Publ. No. 201841044327 A

Group Leader

Dr. A. Jesu Arockia Raj, Professor

Ph.D students - 5 (Pursuing)

Prabha N - Exploration of antimicrobial peptides (AMPs) from innate immune molecules of snakehead fish

Purabi Sarkar - Isolation, identification and molecular characterization of proteins from blue green algae spirulina, Arthrospira platensis

Stefi V. Raju - Discovery, validation and delivery of bioactive peptides from a teleost immune protein and their roles on antimicrobial and possible pharmaceutical application

Manikandan V - Molecular role of peptides possessed different immune properties synthesised from freshwater aquatic organisms

Ajay Guru - Evaluation on antioxidant and antidiabetic activity of WL15 peptide synthesised from Channa striatus using in vitro and in vivo model

Postdoctoral Fellow - 1

Praveen Kumar, I - Identification and bioinformtics characterization of virulent factors from fish disease causing fungus Apahnomyces invadans

Ph. D Awarded - 9

Prashanth Bhatt N - Gene profiling and characterization of chemokines from snakehead murrel Channa striatus

Rajesh P - Molecular functions of selected disease related genes from Channa striatus

Venkatesh, K - Molecular cloning, characterization and gene expression of defense genes from striped murrel  Channa striatus challenged with various immune stimulants

Abirami K - Fish antimicrobial peptides: Bioinformatic  characterization, gene expression and recombinant  protein activities

Akila S - Gene expression and biological activities of immune genes from Channa striatus infected with fungus (Aphanomyces invadans) and bacteria (Aeromonas hydrophilla)

Mukesh Kumar Chaurasia - Gene expression and characterization of a few immune genes from fresh water prawn (Marcobrachium rosenbengii)

Gayathri R. Chandran - Isolation, identification and molecular characterization antimicrobial peptides from murrel skin mucus

Anbazahan S - Molecular characterization of selected antioxidant genes from sprirulina and determination of its biological activities

Kasi Viswananthan M - Development of Feed Additives and their Performances for Sustainable Aquaculture Practice

 

Total No. of Publications                                         : 123

               - Total Impact Factor                                324.405 (as on 30 July 2020)   

               - Citation Number                                     2380 (as on 30 July 2020)

                - H-Index                                                 27 (on 30 July 2020)

Journal Proceeding                                                                                        : 7

Chapters in Books                                                                                         : 4       

Other General & Semi-Scientific Articles in Popular Journal/Magazines      : 61

Papers Presented in International Conferences                                            : 52

Papers Presented in National Conferences                                                   : 38

Attended Workshops/Training Programs                                                        : 19

Invited Talks                                                                                                    : 15     

Programs Conducted                                                                                      : 5       

No. of Ph.D Scholars                                                                                      : 14

Research Projects                                                                                          : 8

Patent Published                                                                                             : 1

GenBank Sequence Submission                                                                    : 285

* in the publications denotes the designation of Corresponding Author

Recent Publications

  • Praveen K, Ajay G, Chandrakumar SS, Lite C, Saraswathi NT, Arasu MV, Al-Dhabi NA, Arshad A, Arockiaraj J* (2020) Molecular process of glucose uptake and glycogen storage due to hamamelitannin via insulin signalling cascade in glucose metabolism. Molecular Biology Reports DOI: 10.1007/s11033-020-05728-5 (in press) (Impact Factor = 1.402)
  • Gayathri R, Mukesh P, Arasu MV, Al-Dhabi NA, Arshad A, Arockiaraj J* (2020) Innate immune function of serine/threonine-protein kinase in Macrobrachium rosenbergii in response to host-pathogen interactions. Fish and Shellfish Immunology DOI: 10.1016/j.fsi.2020.07.068 (in press) (Impact Factor = 3.298)
  • Preetham E, Lakshmi S, Wongpanya R, Vaseeharan B, Arockiaraj J, Olsen E (2020) Antibiofilm and immunological properties of a purified mannose-binding lectin from shrimp Penaeus semisulcatus. Fish and Shellfish Immunology DOI: 10.1016/j.fsi.2020.07.053 ) (Impact Factor = 3.298)
  • Anbazahan S, Madhura R, Mukesh P, Saraswathi NT, Arasu MV, Al-Dhabi NA, Arshad A, Kancahana KM, Arockiaraj J* (2020) Peroxiredoxin of Arthrospira platensis derived short molecule YT12 influenced in antioxidant and anticancer activity. Cell Biology International DOI: 10.1002/cbin.11431 (in press) (Impact Factor = 2.571)
  • Stefi RV, Sarkar P, Kumar P, Arockiaraj J* (2020) Piscidin, fish antimicrobial peptide: Structure, classification, properties, mechanism, gene regulation and therapeutical importance. International Journal of Peptide Research and Therapeutics. DOI: 10.1007/s10989-020-10068-w (in press) (Impact Factor = 1.500)
  • Kumarasan Y, Praveen K, Parimannan S, Kasi M, Aziz A, Paray BA, Arockiaraj J* (2020) Gut microbiota metagenomics in aquaculture: Factors influencing gut microbiome and its physiological role in fishes. Reviews in Aquaculture DOI: 10.1111/raq.12416 (in press) (Impact Factor = 7.772)
  • Sannasimuthu A, Madhura R, Paray BA, Pasupuleti M, Al-Sadoon MK, Alagumuthu TA, Al-Mfarij, AR, Arshad A, Mala K, Arockiaraj J* (2020) Arthrospira platensis transglutaminase derived antioxidant peptide-packed electrospun chitosan/ poly (vinyl alcohol) nanofibrous mat accelerates wound healing, in vitro, via inducing mouse embryonic fibroblast proliferation. Colloids and Surfaces B: Biointerfaces  193: 111124 (Impact Factor = 4.389)
  • Praveen KI, Sarkar P, Stefi RV, Manikandan V, Ajay G, Aziz A, Preetham E, Arockiaraj J* (2020) Pathogenicity and Pathobiology of Epizootic Ulcerative Syndrome (EUS) causing fungus Aphanomyces invadans and its Immunological Response in Fish. Reviews in Fisheries Science and Aquaculture 28: 358-375 (Impact Factor = 3.755)
  • Stefi RV, Purabi S, Pachaiappan R, Paray BA, Al-Sadoon MK, Arockiaraj J* (2020) Defense involvement of piscidin from striped murrel Channa striatus and its peptides CsRG12 and CsLC11 involvement in an antimicrobial and antibiofilm activity. Fish and Shellfish Immunology 99: 368-378 (Impact Factor = 3.298)
  • Anbazahan S, Dhrubjyoti S, Paray B, Al-Sadoon MK, Arockiaraj J* (2020) Intracellular oxidative damage due to antibiotics on gut bacteria reduced by glutathione oxidoreductase derived antioxidant molecule GM15. Archives of Microbiology 202: 1127–1133 (Impact Factor = 1.607)
  • Tripathi VC, Horam S, Singh A, Lata M, Reddy TJ, Arockiaraj J, Mukesh P (2020) The discovery of antioxidants in marine microorganisms and their protective effects on the Hepatic cells from chemical-induced oxidative stress. Free Radical Research 54: 150-161 (Impact Factor = 2.839)
  • Purabi S, Stefi RV, Mukesh P, Paray BA, Al-Sadoon MK, Arockiaraj J* (2020) Antioxidant molecular mechanism of adenosyl homocysteinase from cyanobacteria and its wound healing process in fibroblast cells. Molecular Biology Reports 47: 1821–1834 (Impact Factor = 1.402)
  • Prabha N, Mukesh P, Arockiaraj J* (2020) CxxC zinc finger protein derived peptide, MF18 functions against biofilm formation. The Protein Journal 39:337-349 (Impact Factor = 1.317)
  • Nagaram P, Anbazahan S, Venkatesh K, Preetham E, Arockiaraj J* (2020) Intensifying the anticancer potential of cationic peptide derived from serine threonine protein kinase of teleost by tagging with oligo tryptophan. International Journal of Peptide Research and Therapeutics 26: 75–83 (Impact Factor = 1.500)
  • Vijay R, Soniya C, Mohankumar R, Luxitaa G, Kamatchi M, Melvin G, Arockiaraj J, Dhandapani VE, Angayarkanni N, Malaa K (2019) Cell cycle arrest in peripheral blood mononuclear cells: A non-invasive method for diagnosis of coronary artery disease. Process Biochemistry 84: 153-160 (Impact Factor = 2.952)
  • Elumalai P, Rubeena AS, Vaseeharan B, Chaurasia MK, Arockiaraj J, Olsene RE (2019) Anti-biofilm properties and immunological response of an immune molecule lectin isolated from shrimp Metapenaeus monoceros. Fish and Shellfish Immunology 94: 896-906 (Impact Factor = 3.298)
  • Anbazahan S, Arockiaraj J* (2019) Intracellular free radical scavenging activity and protective role of mammalian cells by antioxidant peptide from thioredoxin disulfide reductase of Arthrospira platensisJournal of Functional Foods 61: 103513 (Impact Factor = 3.701)
  • Kasi V, Venkatesh K, Anbazahan S, Paray BA, Al-Sadoon MK, Arockiaraj J* (2019) Resolving the pathogenicity factors of a novel opportunistic fungus Schizophyllum commune at molecular level. Molecular Biology Reports 46: 3877–3886 (Impact Factor = 1.402)
  • Anbazahan S, Venkatesh K, Shreya A, Mukesh P, Ganesh MR, Mala K, Paray BA, Al-Sadoon MK, Albeshr MF, Arockiaraj J* (2019) Design and characterization of a novel Arthrospira platensis glutathione oxido-reductase-derived antioxidant peptide GM15 and its potent anti-cancer activity via caspase-9 mediated apoptosis in oral cancer cells. Free Radical Biology and Medicine 135: 198-209 (Impact Factor = 6.171)
  • Soyar H, Raj S, Tripathi VC, Garima P, Mitra K, Reddy TJ, Arockiaraj J, Pasupuleti M (2019) Xenobiotic binding domain of Glutathione S-transferase has cryptic antimicrobial peptides. International Journal of Peptide Research and Therapeutics 25: 1477–1489 (Impact Factor = 1.500)
  • Soniya C, Vijay R, Mohankumar R, Kaliappan I, Arockiaraj J, Murugesan S, Mala K (2019), Pharmacological inhibition of guanosine triphosphate cyclohydrolase1 elevates tyrosine phosphorylation of caveolin1 and cellular senescence. European Journal of Pharmacology 848: 1-10 (Impact Factor = 3.263)
  • Venkatesh K, Mukesh P, Bilal AP, Al-Sadoon MK, Arockiaraj J* (2019) Gene profiling of antimicrobial peptides, complement factors and MHC molecules from the skin transcriptome of Channa striatus and its expression pattern during Aeromonas hydrophila infection. Fish and Shellfish Immunology 84:48-55 (Impact Factor = 3.298)
  • Sancho R, Anwesha P, Venkatesh K, Prasanth B, Senthilarasu G, Arockiaraj J, Mukesh P, Vladimir PB, Paromita C (2019) Characterization of some naphthalene utilizing bacteria isolated from contaminated Cooum Riverine sediment of the Bay of Bengal (India). Journal of the Serbian Chemical Society 84: S35–S37 (Impact Factor = 0.828)
  • Preetham E, Rubeena AS, Arockiaraj J, Wongpanya R, Cammarata M, Ringø E, Vaseeharan B (2018) The role of lectins in finfish: A review.  Reviews in Fisheries Science and Aquaculture 27: 152-169 (Impact Factor = 3.755)
  • Anbazahan S, Venkatesh K, Mukesh P, Bilal AP, Al-Sadoon MK, Arockiaraj J* (2018) Radical scavenging property of a novel peptide derived from C-terminal SOD domain of superoxide dismutase enzyme in Arthrospira platensis. Algal Research 35: 519-529 (Impact factor = 4.008)
  • Riar MGS, Ara R, Amin SMN, Kamarudin MS, Wahab MA, Raushon NA, Arockiaraj J, Arshad A (2018) Mouth morphological development of Hilsa (Tenualosa ilisha) larvae collected from Meghna Estuary, Bangladesh. Journal of Environmental Biology 39: 877-882 (Impact Factor = 0.781)
  • Singh LR, Tripathi VC, Raj S, Anoop K, Sampa G, Soyar H, Upadhyay A, Kushwaha P, Arockiaraj J Koneni VS, Mukesh P (2018) In-house chemical library repurposing: a case example for Pseudomonas aeruginosa antibiofilm activity and quorum sensing inhibition. Drug Development Research 79:383-390 (Inmpact factor = 1.902)

 

  • Animal Physiology
  • Environmental Biotechnology
  • Cancer Biology
  • Industrial Biotechnology
  • Genomics and Proteomics