Ms.B. Sathya

Senior Research Fellow
Area: Bioinformatics
Email ID:sathya.b@ktr.srmuniv.ac.in                                                                                                                                                                                        
Affiliation: Department of Genetic Engineering, Kattankulathur Campus, SRM Institute of Science and Technology, (formerly known as SRM University)

Education

Other Details:

Research Interest

• Pharmacophore Modeling
• Screening of large virtual compound libraries
• Molecular dynamics simulation
• Quantitative Structure Activity Relationship Study

Selected Publications

• Sathya B, Santhosh Kumar N, and Thirumurthy M (2019). Investigation of Empirical and Semi‐Empirical Charges to Study the Effects of Partial Charges on Quality and Prediction Accuracy in 3D‐QSAR. Chemistry Select, vol. 4, pp.3990 –4002.
• Sathya B, Santhosh Kumar N, and Thirumurthy M (2019). Understanding the structural features of JAK2 inhibitors: a combined 3D-QSAR, DFT and molecular dynamics study. Mol Diversity.
• Santhosh Kumar N, Sathya B, Sohn H, Panneer D, and Thirumurthy M (2018). Towards a better understanding of the interaction between Somatostatin receptor 2 (SSTR2) and its ligands: a structural characterization study using molecular dynamics and conceptual Density Functional Theory (DFT). Journal of Biomolecular Structure and Dynamics, vol. 17, pp.1-22.
• Santhosh Kumar N, Sathya B, and Thirumurthy M (2017). Theoretical analysis of somatostatin receptor 5 with antagonists and agonists for the treatment of neuroendocrine tumors. Molecular Diversity, vol. 21(2), pp.367-384.
• Santhosh Kumar N, Sathya B, Sohn H, Panneer D, and Thirumurthy M (2017). 3D-QSAR studies on indole and 7-azoindole derivatives as ROCK-2 inhibitors: An integrative computational approach. Computational Biology and Chemistry, vol. 71, pp.104-116.
• Sathya B, Rupa M, Santhosh Kumar N, Sohn H, and Thirumurthy M (2016). Molecular Modeling Study on Diazine Indole Acetic Acid Derivatives for CRTH2 Inhibitory Activity. Combinatorial Chemistry & High Throughput Screening, vol. 19(6), pp.444-460.
• Sathya B, Santhosh Kumar N, Hang Lee S, and Thirumurthy M (2016). Structural characterization of human CRTh2: a combined homology modeling, molecular docking and 3D-QSAR-based in silico approach. Medicinal Chemistry Research, vol.  25(4), pp.653-671.
• Sathya B, Kulkarni S.A, Sohn H and Thirumurthy M (2015). Identification of leads through insilico approaches utilizing benzylthio-1H-benzo[d]imidazol-1yl acetic acid derivatives: A potent CRTh2 antagonist. Journal of Molecular Structure, vol. 1102, pp. 25-41.
• Sathya B, Sohn H, and Thirumurthy M (2015). Computational analysis of CRTH2 receptor antagonist: A Ligand- based CoMFA and CoMSIA approach. Computational Biology and Chemistry, vol. 56, pp. 109-121.
• Sathya B, Akila Parvathy D, Ramesh Kumar G (2015). NGS Meta data analysis for identification of SNP and INDEL patterns in human airway transcriptome: A preliminary indicator for lung cancer, Applied & Translational Genomics, vol.4, pp. 4-9.

Work in Progress

• Identifying the potent lead compounds for Janus Kinase enzymes (JAK).
• Optimizing the available JAK inhibitors using Quantitative Structure Activity Relationship Study.

Achievements and Awards

• Awarded with CSIR-SRF fellowship