Dr. A. Devi, 

PDF: University of Alberta, Canada; University of Washington, USA

Associate Professor
Area: Cancer Research and Stem Cell Biology
Affiliation: Department of Biotechnology, School of Bioengineering, Kattankulathur Campus, SRM Institute of Science and Technology (formerly known as SRM University)
Email: devia@srmist.edu.in

Education

Other Details

Courses

• Stem Cell Biology
• Animal Cell Culture and Transgenic Technology
• Cell Biology
• Gene Therapy
• Animal Cell Culture Laboratory
• Gene Expression Laboratory

Research Interests

• Signalling pathways in Cancer
• Isolation of Stem Cells
• Genetics of Cardiovascular Diseases

No: of Ph.D Scholars Guiding  : 2

No: of Ph.D Scholars Completed: 4

Selected Publications

• Joel P. Joseph, M.K. Harishankar, Aruthra Arumugam Pillai, Arikketh Devi. (2018) Hypoxia induced EMT: A review on the mechanism of tumor progression and metastasis in OSCC. Oral Oncology. 80:23-32.
• K.N.ArulJothi, B. Suruthi Abirami, Arikketh Devi. (2018) Genetic spectrum of low density lipoprotein receptor gene variations in South Indian population. Clinica Chimica Acta. 478:28-36.
• Dannie M, Joel J, Aruthra PA, Devi. A (2017) Eminent sources of adult mesenchymal stem cells and their therapeutic imminence, (DOI: 10.1007/s12015-017-9759-8). Stem Cell Reviews and Reports. 10 (6):1-16.
• Harishankar MK, Sharon Prince, A. Mathan Mohan,  K. Vinod Krishnan, Arikketh Devi A. (2016)  Association of Notch4 with metastasis in human oral squamous cell carcinoma. Life Sciences.  156, 38-46.
• ArulJothi KN, Whitthall RA, Futema M, Humphries SE, George Melvin, Elangovan S, Nair Devaki R., Devi A. (2016) Molecular analysis of the LDLR gene in coronary artery disease patients from the Indian population. Clinical Biochemistry.  49, 669–674, doi: 10.1016/j.clinbiochem.2016.02.009
• Henrik Sperber, Julie Mathieu, Yuliang Wang, Amy Ferreccio, Jennifer Hesson , Zhuojin Xu, Karin A. Fischer, Arikketh Devi, et al., (2015) The metabolome regulates the epigenetic landscape during naive to primed human embryonic stem cell transition.  Nature Cell Biology.  17 (12), 1523-1535.
• Harishankar MK, Logeshwaran S, Sujeevan S, Aruljothi KN, Dannie MA, Devi A. (2015) Genotoxicity evaluation of metformin and glimepiride by micronucleus assay in exfoliated urothelial cells of type 2 diabetes mellitus patients. Food Chem Toxicol. 83: 146 – 150.
• Arumugam SB, Trentz OA, Devi Arikketh, Senthilnathan V, Rosario B,   Mohandas P. (2011)   Detection of embryonic stem cell markers in adult adipose-tissue derived stem cells. Indian J Pathol  Microbiol. 54: 501-8.
• OA Trentz, D. Arikketh, V Senthilnathan, S Hemmi and AE Handschin et al., (2010) Surface proteins and osteoblast markers: characterization of human adipose tissue-derived osteogenic cells. Eur. J Trauma and Emer. Sur. 36:457-463.
• Devi Arikketh, Randy Nelson and Jean E. Vance. Defining the importance of Phosphatidylserine Synthase – 1 (PSS1): Unexpected viability of PSS1- deficient mice. (2008) Journal of Biological Chemistry. 283 (19): 12888-12897.
• Devi Arikketh and Devaraj H. (2006) Induction and expression of GST-Pi foci in the liver of Cyclophosphamide administered rats. Toxicology.  217 (2): 120-128.
• Arikketh Devi, Niranjali S. and Devaraj H. (2004). Detection of acrolein lysine adducts in the plasma low density lipoprotein and in aorta of Cyclophosphamide-administered rats. Arch. Toxicol. 78 (7) :397-401.

Working Papers

• Stem Cell Markers Review.
• Systematic review and meta-analysis of prognostic microRNA biomarkers for survival outcome in nasopharyngeal carcinoma.
• Millets and their nutraceuticals.
• Dental Pulp Stem Cells.
   

Work in Progress

• Currently working on an Indo-South Africa Project on “Evaluation of nutraceuticals derived from indigenous millets for anti-tumorigenic activity and its action on the potential therapeutic targets, Notch4 and TBX3, in OSCC” funded by DST, India with Prof. Sharon Prince, University of Cape Town, SA .
• Collaborating with Prof.Hannele Ruohola Baker, Institute of Stem Cell and Regenerative Medicine, University of Washington, USA on Dental pulp derived stem cells.

Papers Presented

• Arul Jothi KN and Devi.A, Genetic spectrum of Low Density Lipoprotein Receptor (LDLR) gene: A report of novel and recurrent variations observed in Indian population, Indian Genetic Congress, 2015.
• ArulJothi. KN and Devi.AThe paper presentation award for "Best Science and Technology Project" in National level conferene on "Advances in Biotechnology and Health Sciences" held at Dr.MGR Research and Education University, Chennai

Academic Experience

• Lecturer (Part-time), University of Madras, Guindy Campus, Chennai (1998-1999)
• Lecturer in Biotechnology, Women's Christian College (2005-2006)
• Post-doctoral fellow, Molecular and Cell Biology of Lipids Group (MCBL), University of Alberta, Edmonton, Alberta, Canada (2006-2007)
• Post-doctoral fellow, Molecular and Cell Biology of Lipids Group (MCBL), University of Alberta, Edmonton, Alberta, Canada (2006-2007)
• Research Scientist, MIOT Institute of Research, MIOT Hospitals, Chennai (2009-2011)
• Visiting Faculty, University of Washington, USA (Jan-June, 2015)

Other Professional Experience

• Member of the Institutional Committee on Stem Cell Research (IC-STR) of Medical Park, Chennai.    
• Certified  course on Animal Care and Use conducted by the University of Alberta, Edmonton, Alberta, Canada, 2006. 
• Certified course on Radiation Safety conducted by the University of Alberta, Edmonton, Alberta, Canada, 2006.
• Online Courses on Bloodborne Pathogens for Researchers, Biosafety Training, Safety Training, GPS-Globally Harmonized System conducted by University of Washington, USA.

Workshops /Seminars/Conferences

• Invited Speaker in The landscape of Genetic Variants in Asian Founder populations-2nd International Conference on Founder Populations on the topic “Genetic and Molecular Analysis of Hypercholesterolaemia”, Nov 9th-12th, 2017, Kochi, India.
• Invited Speaker in the Educational Programme for General Practitioners on Familial Hypercholesterolemia on the topic “ Structure and functions of LDL receptor gene and its mutation spectrum” conducted by Department of Community Medicine, Cardiology, SRM MCH and RC and School of Public Health, SRM University on 24th August, 2015.   
• Participated in the workshop on “Outcome based accreditation process and parameters” at  SRM University, on Nov 8th, 2012.
• National Symposium on Physiology and Biochemistry of cultivable Crustaceans- 2002, conducted by the University of Madras, Department of Zoology, Chennai- 600 025.
• National Seminar on Frontier Areas of Research in Life Sciences-2003 conducted by the University of Madras, Department of Zoology, Chennai-600 025.
• Indo-Australian Conference on Biotechnology in Medicine –2004, conducted by the Indian Institute of Science, Bangalore.
• Awareness Programme on Application of Radioisotopes and Radiation Technology for Societal Development (ARRTS – 2004) conducted by Anna University, Chennai.
• 5th Annual Conference on Genetic and Molecular Diagnosis in Molecular Medicine, 2012, Dept. of Genetic Engineering, SRM University, India.

Funded Projects

• Principal Investigator, Evaluation of nutraceuticals derived from indigenous millets for anti-tumorigenic activity and its action on the potential therapeutic targets, Notch4 and TBX3, in OSCC. DST and NRF (2016-2019) (Indo-South Africa), Govt. of India (Rs.28.57 lakhs)
• Genetic and Molecular analysis of human Low Density Lipoprotein receptor (LDLR), Apolipoprotein B (APOB) and Proprotein Convertase  Subtilisin/kexin 9 (PCSK9) genes in Familial Hypercholesterolemia (FH)   patients of South Indian population, SRM Research excellence Award   (2016-2017)

Achievements and Awards

• Passed the TamilNadu State Eligibility Test  for Lectureship  (SET-2006),  conducted by the Bharathiar University  in March, 2006.
• Awarded proficiency for B.Sc and 20th  rank in the University Examination, University of  Madras, 1991.
• Recipient of award for outstanding science students during 1988-1989 under the Jawaharlal Nehru Science Talent Scheme from the Department of Education, Government of Tamil Nadu, India, 1988.

Memberships

• Member of European Atherosclerosis Society - Familial Hypercholesterolemia Studies Collaboration (EAS FHSC)
• Member in Indian Society of Human Genetics, 2011
• Member in Indian Science Congress Association, 2011